ABSTRACT
MicroRNA (miRNA) is a kind of highly conserved microRNA molecules that regulate gene expression after transcriptional levels in eukaryotes. Numerous evidences indicate that miRNA can regulate malignant phenotypes of neoplasms by repressing the expressions of critical oncogenes or tumor suppressor genes, and abnormal expression of miRNA becomes one of the most important features of cancer. The expression of miR-29b was low in multiple types of tumors and its up-regulated expression will depress the expression of some target genes, which plays a crucial role in the occurrence and development of various neoplasms and is expected to serve as a biomarker for early diagnosis and prognosis assessment becoming a novel target of drug development and new treatment.
ABSTRACT
MicroRNA (miRNA) is a kind of highly conserved microRNA molecules that regulate gene expression after transcriptional levels in eukaryotes. Numerous evidences indicate that miRNA can regulate malignant phenotypes of neoplasms by repressing the expressions of critical oncogenes or tumor suppressor genes, and abnormal expression of miRNA becomes one of the most important features of cancer. The expression of miR-29b was low in multiple types of tumors and its up-regulated expression will depress the expression of some target genes, which plays a crucial role in the occurrence and development of various neoplasms and is expected to serve as a biomarker for early diagnosis and prognosis assessment becoming a novel target of drug development and new treatment.
ABSTRACT
Objective To assess the significance of intima‐media thickness(IM T )combined with HCY ,HbA1c and blood lipid in‐dexes in patients with cerebral infarction .Methods 100 cases of patients with cerebral infarction were enrolled in the experiment group ,and were divided into normal blood glucose group ,high blood glucose group and diabetes mellitus(DM)group .60 healthy in‐dividuals were enrolled in the control group .The serum leves of HCY and HbA1c were detected ,and the IMT was determined by u‐sing ultrasonic examination .Results The positive rate of increase of IMT in the exprement group(70% ) were higher than that in the control group(10% ) ,there were significant differences between the two groups (P<0 .05) .The levels of HCY and HbA1c and IMT were higer in the exprement group compared withthose in the control group ,there was significant difference between the two groups(P<0 .05) .The serum levels of HbA1c and IMT were higher in the high blood glucose group and the DM group compared with those in the control group ,there were significant differences between the two groups (P<0 .05) .The sensitivity ,susceptibility and accuracy of IMT combined with HCY ,HbA1c and blood lipid indexes were 97 .1% ,87 .5% and 94 .0% .Conclusion The ultra‐sonic examination combined with biochemical indexes related to cerebral infarction could increase detection rate of cerebral infarc‐tion ,and the ensitivity ,susceptibility and accuracy could also increase .
ABSTRACT
The present paper reports the distribution of ALADH phenotypes in 170 Chinese peoples living in Nanjing area by means of the mixed starch get electrophoresis. The gene frequencies are ALADH~1=0. 359, ALADH~2=0.641, which are compared with the gene frequencies of some other countries.